Natural Products – Methods and Optimal NMR Techniques

Introduction to Natural Products for Drug Discovery Research and Beyond

Topics:

Sourcing of raw material
Extraction techniques
Multi-step purification techniques for screening and NMR data acquisition
Sample preparation and handling at the microgram scale
NMR Probe options
NMR sample preparation and handling at the micro-liter scale
NMR experiments and optimizations
Data manipulation and interpretation

Remarks:

From isolation, purification to structure elucidation, natural products presents many different and varied challenges in creating pure samples from limited biomass. The course offers an introduction into the complexities of working with natural products from a drug discovery perspective. This course will focus mainly on plant biomass but can be extrapolated to include any natural product source. The user will experience all of the analytical techniques included in a patented (US Patent 7,367,933) natural product library production process, to isolate NMR ready samples. From here, the course will cover working with compounds at the microgram and micro liter scale, from sample creation to sample transfer. Basic and optimal NMR experiments will be covered including post processing of all NMR data. Structure elucidation approaches will include starting points of software choices, data manipulation and structure proposal and verification.

Prerequisite Qualification:

Open to all AVANCE spectrometer users.

Date and Place:

March 16, 2011 in Fällanden/Zürich
September 7, 2011 in Fällanden/Zürich

Course Cost and Duration:

Course Cost¹	Duration	Language
€390.00 (incl. documentation, coffee breaks, and lunch)	1 Day	English

Course Schedule:

Course day:	9:30 - 5:30 p.m.

Course Coordination:

Bruker BioSpin AG
Mrs. Svetlana Startseva
Industriestrasse 26
CH-8117 Faellanden
Phone: +41-44-825 95 42
Fax: +41-44-825 95 50
E-Mail: svetlana.startseva(at)bruker-biospin.ch

¹Prices are subject to change without notice