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Hyphenation Systems
NMR solutions with hyphenated techniques
Hyphenated analytical techniques combining mass spectrometry and chromatography are well-established laboratory tools. The combination of chromatography and NMR has also made its way into the analytical laboratory.
Further developments even combine all three techniques into an LC-NMR/NMR-MS system. The use of solid phase extraction provides an efficient interface between chromatography and NMR with demands for special type of flow probes.
Hyphenated analytical techniques combining mass spectrometry and chromatography are well-established laboratory tools. The combination of chromatography and NMR has also made its way into the analytical laboratory. Further developments even combine all three techniques into an LC-NMR system.
Metabolic analysis typically employs large numbers of samples and sophisticated statistical procedures to discover the trends in the data. NMR and LC-MS are the main analytical technologies used, therefore, it is logical to progress from the application of high-throughput flow-injection NMR to a configuration which includes the connection to a high-resolution TOF-LC-MS system.
A Solid Phase Extraction (SPE) system provides an interface between liquid chromatography (LC) and NMR. For the process of LC-SPE™ NMR a chromatographic separation is done and the peaks of interest are trapped on an individual SPE cartridge after the column. The peak selection is done either by UV detection or by evaluation of the on-line registered MS or MSn spectra.