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- MRI Newsletter 05/2010
- Bruker Introduces New Ascend™ High Performance High-Field NMR Magnet Series
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SampleRail
High Throughput Automated Protein and Protein-ligand Interaction Screening
The SampleRail™ allows high throughput automated protein and protein-ligand interaction screening, which leads to substantial time-saving in the modern automated laboratory. Another major advantage is Ligand Pooling, which allows use and mixing of a variety of ligands for NMR experiments.
The SampleRail is part of a system under the management of the SampleTrack™ Laboratory Information Management System and ICONNMR™ automation software, that provides automatic preparation and mixing of multiple compounds, and subsequent NMR measurements.
- Protein-ligand interaction with ligand pooling.
- Titration cycles.
- Barcode sample identification.
- Manual insertion mode.
- Controlled by ICON-NMR automation software and the SampleTRACK Laboratory Information Management System
A typical application example is the protein-ligand binding detection by NMR. This system automatically prepares an NMR sample, inserts it into an NMR magnet, performs NMR experiments on the sample, and transports it back to the preparation system.
The SampleRail fulfills the transporting tasks from the preparation system into the NMR magnet and back, while a TECAN Freedom EVO® pipetting robot is used as the preparation system. The SampleRail may also be used in a "manual insertion mode" to insert and eject single NMR probes manually into the NMR magnets.