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Molecular Imaging
SPIO-Labeled Macrophage Infiltration
These data were acquired using a BioSpec® 47/40.
Three-dimensional (3D) MR images were obtained from the knees of rats in a model of antigen-induced arthritis. Imaging macrophage infiltration could provide an early marker of disease progression, before more aggressive changes like cartilage and bone erosion take place. Monitoring early changes associated with arthritis can have an impact in preclinical studies by shortening the duration of the experimental period and by facilitating the investigation of novel immunomodulatory therapies acting on macrophages.
- Histological analysis in the areas indicated in the MR image depicts iron-loaded macrophages.
Copyright and courtesy of N. Beckmann et al.
Novartis Institutes for Biomedical Research Basel, Switzerland