HyperQuant

HyperQuant™ is Bruker BioSpin's new bench-top NMR reader for precisely quantifying hyperpolarization and thermal polarization, i.e., the enhancement factor. The new HyperQuant offers a complete off-the-shelf turnkey solution.

 Bruker BioSpin's proprietary solution applies a 0.94 Tesla unique permanent magnet system combined with an innovative MR probe design (patents pending) and its fully flagged NMR pulse sequence capabilities. This unparalleled combination enables quantification of the thermal polarization level of ¹³C-labeled samples using volumes as low as 1 ml. Thus, Hyperpolarization enhancement factors can be obtained directly on the sample of interest, without having to go via a separate calibration reference.

Today, hyperpolarization promises to be a very useful technique with its potential to boost sensitivity and selectivity in MRI and high-resolution NMR. Hyperpolarization provides a means to increase the polarisation by orders of magnitude (enhancement factors of 100,000) from the otherwise physical limit of the Boltzmann polarization. Hyperpolarization can be obtained by various mechanisms, both physical and chemical in nature, like DNP (dynamic nuclear polarization) and parahydrogen induced polarization (PHIP). Typically labelled Carbon-13 samples are utilized because of the preferential MR properties of the ¹³C.