Quantification

HyperQuant

Direct Quantification

: Decay of the Hyperpolarized 13C signal

HyperQuant delivers a unique direct quantification of the enhancement factor, by being able to measure both the hyperpolarized and the thermally polarized state of the 13C sample. Thus, it does not require a separate calibration reference.

The hyperpolarization is quantified by using a carefully calibrated small flip angle excitation pulse. The measurement hardly affects the polarization state of the sample. Alternatively, HyperQuant can also closely trace the decay rate of the hyperpolarization.

Thermal Polarization

The thermal polarization of 13C labeled samples is enabled by a unique combination of a 0.94 T magnet, a high Q ¹³C probe (10 MHz) and a multipulse NMR sequence. The plug-and-play concept of the probes allows for easy exchange and handling. In addition, 40 MHz ¹H probes are also available.

Pulse Flip Angle Calibration

Key to the precise determination of the enhancement factor is the automatic flip angle calibration to determine and validate both the 90° and 180° pulse length.

13C Measurement

: 13C TD-NMR signal of the thermally polarized sample with statistics on the superior repeatability.