Drug Discovery

NMR is a major tool for pharmaceutical drug discovery, both in the traditional areas of structure determination and characterisation, and also increasingly for binding studies to screen candidate molecules - this can also feed back affinity information to the drug design process.  With these latest advances and applications, NMR is poised to assume a greater role in the pharmaceutical and biotech industries.
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The challenge is to deliver the essential measurement stability and repeatability required for generating source spectra, and then to offer automated technology for handling numerous samples, together with easy to use software for both instrument control and data analysis.
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Longer acquisition times typically associated with low protein concentrations can be overcome using cryogenic NMR probe technology which dramatically increases sensitivity. CryoProbes enhance high-resolution NMR and increase the signal-to-noise ratio up to fourfold, allowing larger compound libraries to be rapidly screened using smaller amounts of protein - making NMR highly suited for High Throughput Screening (HTS).
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