TCI 1.7 mm MicroCryoProbe™

Bruker Biospin’s 1.7 mm TCI MicroCryoProbe™ is the ultimate tool commercially available for unparalleled mass sensitivity. The sample volume of 30 µL offers more than an order of magnitude mass sensitivity compared to the conventional 5 mm probe. It’s TCI design allows for highest 1H sensitivity and also for
enhanced performance on the carbon channel.

This extreme sensitivity jump makes the 1.7 mm MicroCryoProbe an ideal tool for any NMR analysis with limited sample amounts, e.g. natural products, isolated low abundance proteins, peptides or small molecules, difficult-to-express proteins, etc.

For many “real life” samples the use of this probe has been the only way to obtain spectra that allowed solving difficult problems. Natural products, where often only submicrogram quantities are available or biological samples where the expression does not yield large quantities or where the screening of thousands of compounds benefits from reduced target quantities, all these applications have received a significant boost by the use of the 1.7 mm TCI MicroCryoProbe. 

For a given amount of material a 14-fold gain over a conventional 5 mm probe and a 6-fold gain over a conventional 1.7 mm probe is realized. In some cases this can lead to an over 200-fold reduction in experiment time. 
A 2008 R&D 100 Award has been presented to Bruker BioSpin for its 1.7 mm triple resonance NMR MicroCryoProbe™ with breakthrough sensitivity on a sample volume of only 30 µL.