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Coil-on-a-Chip™ Technology
Surface Microcoils for MR Imaging

- Isolated mouse brain at 5x5x5μm3 isotropic resolution

- Surface redering (Courtesy: S. Blackband et al., NHMFL, Univ. of Florida)
Modern magnetic resonance micro-imaging applications require the investigation of submillimeter samples at very high isotropic spatial resolution of 10 μm and less. A technological breakthrough for these applications is Bruker BioSpin’s new Coil-on-a-Chip™ micro-imaging technology.

- Silicone oil beads.
Based on surface microcoils with diameters as small as 20 μm, a gain in mass-sensitivity up to a factor of 50 compared to conventional 5 mm micro-imaging coils can be achieved. This allows 3D MR imaging with a voxel volume of only 1 picoliter in less than one hour. The new microcoils can be used as exchangeable inserts in vertical bore magnets and are compatible with standard micro-imaging probes.
Coil-on-a-Chip Technology provides:
- Ultimate mass-sensitivity for MR imaging a high resolution of 10 μm and less
Imaging of small samples with reduced field of view of 1 mm2 and below
- Ease of use since the sample can simply be eposited directly on to the chip surface
- Exchangeable insert technology for full ompatibility with existing Bruker micro-imaging hardware and software
About Coil-on-a-Chip Technology

- Coil-on-a-Chip technology is based on a state-of-the-art microfabrication
Similar to the process used in the fabrication of microelectronic circuits, Coil-on-a-Chip technology is based on a state-of-the-art microfabrication process developed specifically to satisfy the unique requirements set by NMR applications.
The use of photolithography enables the fabrication of very small structures with a high degree of precision and reproducibility. This guarantees high performance,
even for extremely miniaturized coils.
With Coil-on-a-Chip technology, NMR steps into the world of Lab-on-a-Chip devices. By making it possible to work efficiently with small volume samples, Lab-on-a-Chip devices are revolutionizing the world of chemical and biological analysis.

