SmartProbe

Sensitive, Versatile, Flexible, .... Smart

Highest Sensitivity combined with Optimum Versatility and Flexibility for Routine NMR Applications

: Decaborane 11B NMR

: Decaborane 11B NMR with and without 1H decoupling: recorded with NS=1

Boron NMR

Boron is a common element used in inorganic and organic compounds. The spectra of decaborane show ¹¹B-NMR spectra with and without proton decoupling. The 2D COSY was recorded in just a few minutes.

: 1 mg/ml fluorouracil 19F, 1H HMBC: 2 min

: 1 mg/ml fluorouracil 19F, 1H HOESY and 19F, 1H HMBC

Fluorine NMR

Fluorine is an element found in many pharmaceutical compounds. Essential structural parameters are accessible with heteronuclear NOE experiments, like the HOESY experiment. Fluorine is also used as a spy for studies of the metabolism of active agents, and for enzymatic HTS screening.

(Top) ¹⁹F, ¹H HMBC Experiment of cytostaticum fluorurazil. The correlation shows a spatial neighbourhood to the proton of the heterocycle.

(Bottom) Comparison of the ¹⁹F, ¹H HOESY and HMBC experiment. While the HOESY spectrum has a correlation to the proton of the heterocycle, the HMBC shows a correlation to the NH protons.

: 50mM quinine-1D selective NOESY: only 30 seconds for each experiment

Structure Verification and Elucidation

¹⁵N detection experiments and structural work

Structure verification and determination require high quality spectra, which are characterized by excellent lineshape for all nuclei and high sensitivity for all experiments. Well balanced rf channels and matched B1 homogeneity of all coils are a prerequisite, if best sensitivity is to be obtained for any type of application. Excellent solvent suppression enables applications in water, like biomolecular experiments and metabonomic studies.